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H. Shekhar
Manoj Kumar


SLE, Mixing and excessthermodynamic functions, thermal stability, Interfacial energy, Driving force of nucleation, Critical radius


With view to synthesize and characterize the enhanced pharmaceutical properties of the solid-liquid dispersions of binary drug system through green chemical technique the present communication have been undertaken for detailed investigation of thermodynamic and interfacial properties of benzimidazole (BI) and β. naphthol (βN) binary eutectic and non-eutectic drug dispersions. Eutectic solid dispersion was observed at 0.657 mole fraction of β. naphthol (βN) and at melting temperature 90°C.

Thermodynamic quantities; Partial and Integral  excess Gibbs energy (gE), excess enthalpy (hE), excess entropy (sE) of eutectic and non-eutectic dispersions were determined with the help of activity coefficient data. The negative deviation from ideal behaviorhas been seen in the system which refers stronger association between unlike molecules during formation of binary mix. The negative value of Gibbs free energy of mixing (DGM) refers the mixing for all eutectic and non-eutectic dispersions is spontaneous. The solid-liquid interfacial characteristics i.e., entropy of fusion per unit volume (DSV), solid-liquid interfacial energy (s), roughness parameter (α), grain boundary energy and roughness parameter (α) of eutectic and non-eutectic solid dispersions have been reported.

The size of critical nucleus at different undercoolings has been found in nanoscale, which may be a big significance in pharmaceutical world. The value of roughness parameter, α > 2 was observed which manifests the faceted and irregular growth leads in the system.


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